CORE Documentation
CORE – A Cell-Level Coarse-to-Fine Image Registration Engine for Multi-stain Image Alignment.
CORE is a fast and accurate coarse-to-fine image registration engine designed for aligning multi-stain whole-slide images (WSIs). It combines prompt-based tissue masking, rapid coarse alignment, and nuclei-level fine registration to deliver precise cell-level correspondence across stains.
Figure 1. End-to-end CORE pipeline: from raw WSI input through preprocessing, tissue masking, coarse rigid/elastic registration, fine nuclei-level registration, to TRE evaluation.